With the Ambulance Drone, it is possible to deliver defibrillation to any patient in a 12 km2 area within 1 minute. At that speed, survival rates can be as high as 80%. Secondly, the incorporation of a two-way, video supported, communication channel in the drone between 112 operators and the first responders will improve first care. Successful AED usage by lay-persons is currently at 20%. With personalized instructions and communication on the Ambulance Drone, this can be increased to 90%. In short, the Ambulance Drone helps to save lives by extending existing emergency infrastructure with a network of fast and compact UAVs capable of bringing emergency supplies and establishing communication, anywhere. Furthermore, the high unemployment rate may be targeted through the solution using young gamers as drone operators.