CADence™ is designed to detect significant coronary stenosis through an innovative, non-invasive, radiation-free test. Diagnose obstructive coronary artery disease in patients presenting with chest pain and two or more risk factors. Acoustical detection with CADence™ provides a completely new method for detecting significant coronary stenosis. Cardiovascular disease is the leading cause of death in both men and women in the United States, and is a major cause of death throughout the world. According to an American Heart Association report, 1 of every 3 deaths in the United States is caused by cardiovascular disease. Out of all cardiovascular diseases, coronary atherosclerosis ranked number one in cause of death and cost.