Parkinson’s disease, essential tremor, SCA and hyperthyroidism may cause muscle stiffness and shaking in hands. HANDLE is a rehabilitation device designed to improve these symptoms and to be operated by one or both hands. It can be used with tablet games for hand balancing and muscle strength training, and improve reaction time and thinking skills. The course of disease is usually divided into five stages. Through the grasp detector and the tablet games, HANDLE can record the rehabilitation status to adjust the game difficulty level. As a combination of rehabilitation and entertainment, HANDLE improves the quality of life of patients.